Exploring skin aging-associated genotypes; Moving toward delivery of precision medicine-based care more than beyond skin deep care: a genome-wide association study

Table 6 Comparison of intrinsic skin aging items between genotypes

Skin aging score: SCINEXA		Genotype
Skin aging symptoms		rs2234922			rs1051740			rs1800566
Skin aging symptoms		AA	AG	GG	TT	TC	CC	GG	GA	AA
Score of uneven pigmentation
3		1	97	97	3	75	98	0	63	126
0		5	0	0	24	0	0	11	0	0
	p-value	0.22	0.03	0.03	0.51	0.02	0.03	0.46	0.01	< 0.001
Score Fine wrinkles
3		1	49	79	2	43	51	0	39	84
2		1	38	14	4	30	33	1	13	33
1		2	10	4	11	2	14	1	11	9
0		2	0	0	10	0	0	9	0	0
	p-value	0.12	0.03	0.07	0.61	0.03	0.01	0.29	0.03	0.05
Score Lax appearance
3		0	52	58	1	14	61	0	22	48
2		0	32	27	1	59	28	0	35	63
1		1	13	13	22	2	9	9	6	15
0		5	0	0	3	0	0	2	0	0
	p-value	0.11	0.06	0.04	0.14	0.01	0.05	0.33	0.04	0.07
Score Reduced fat tissue
3		0	22	39	0	27	41	0	19	79
2		0	54	51	0	38	29	6	44	33
1		3	21	7	25	10	28	3	0	14
0		3	0	0	2	0	0	2	0	0
	p-value	0.21	0.02	0.01	0.23	0.03	0.04	0.59	0.08	0.06
Score Benign skin tumors
3		2	13	15	0	6	23	0	11	31
2		3	55	43	0	37	5	0	35	59
1		1	29	39	8	30	70	4	17	26
0		0	0	0	19	2	0	7	0	10
	p-value	0.24	0.03	0.06	0.19	0.01	0.03	0.12	0.03	0.04

ISSN: 1471-2318