Exploring skin aging-associated genotypes; Moving toward delivery of precision medicine-based care more than beyond skin deep care: a genome-wide association study

Table 4 Hardy–Weinberg equilibrium for genetic sample with rs2234922 (A > G), rs1051740 (T > C) and rs1800566 (G > A) polymorphisms

SNP	Gene		Genotypes					Ancestral allele	MAF	χ²	HWE p-value
SNP	Gene		AA	AG	GG	A	G	Ancestral allele	MAF	χ²	HWE p-value
rs2234922	EPHX1	Observed	6	97	99	54	146
		Expected	106	79	15	Not detected		A	G = 0.2155/1079 (1000 Genomes)	0.001	8.948
			TT	TC	CC	T	C
rs1051740	EPHX1	Observed	27	75	98	65	135	T	C = 0.3133/1569 (1000 Genomes)	0.0926	4.762
rs1051740	EPHX1	Expected	92	87	21	Not detected		T	C = 0.3133/1569 (1000 Genomes)	0.0926	4.762
			GG	GA	AA	G	A
rs1800566	NQO1	Observed	11	63	126	43	157	G	A = 0.2889/1447 (1000 Genomes)	0.6844	0.269
rs1800566	NQO1	Expected	124	67	9	Not detected		G	A = 0.2889/1447 (1000 Genomes)	0.6844	0.269

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