Cognitive domain | Locomotion domain | Psychological domain | Vitality domain | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline characteristics | Group 1 | Group 2 | Group 3 | Group 1 | Group 2 | Group 3 | Group 1 | Group 2 | Group 3 | Group 1 | Group 2 | Group 3 | ||||||||
N | 129 | 103 | 62 | 27 | 63 | 204 | 84 | 157 | 53 | 120 | 129 | 45 | ||||||||
Sex (N, %) | p = 0.02 | p = 0.006 | p = 0.11 | p = 0.45 | p = 0.92 | p = 0.71 | p = 0.22 | p = 0.23 | ||||||||||||
Female | 87 (67%) | 84 (82%) | 54 (87%) | 18 (67%) | 53 (84%) | 154 (75%) | 63 (75%) | 120 (76%) | 42 (79%) | 86 (72%) | 102 (79%) | 37 (82%) | ||||||||
Male | 42 (33%) | 19 (18%) | 8 (13%) | 9 (33%) | 10 (16%) | 50 (25%) | 21 (25%) | 37 (24%) | 11 (21%) | 34 (28%) | 27 (21%) | 8 (18%) | ||||||||
Age, mean (SD) | 85.1 (7.76) | 86.3 (6.77) | p = 0.46 | 86.9 (7.23) | p = 0.25 | 81 (7.70) | 85.98 (6.67) | p = 0.002 | 86.54 (7.26) | p < 0.001 | 84.80 (8.27) | 86.35 (7.31) | p = 0.33 | 86.30 (5.52) | p = 0.57 | 85.47 (7.05) | 85.31 (7.33) | p = 0.73 | 88.81 (7.52) | p = 0.001 |
ADL at baseline (N, %) | ||||||||||||||||||||
0 (Severe dependency) | 9 (7%) | 6 (6%) | p = 0.93 | 13 (21%) | p = 0.009 | 0 (0%) | 1 (2%) | p > 0.9 | 27 (13%) | p = 0.09 | 4 (5%) | 17 (11%) | p = 0.17 | 7 (13%) | p = 0.14 | 3 (2%) | 9 (7%) | p = 0.17 | 16 (36%) | p < 0.001 |
[1–3] (Moderate dependency) | 38 (29%) | 41 (40%) | p = 0.13 | 36 (58%) | p = 0.001 | 2 (8%) | 12 (19%) | p = 0.03 | 101 (50%) | p < 0.001 | 24 (28%) | 69 (44%) | p = 0.02 | 22 (42%) | p = 0.16 | 29 (24%) | 68 (53%) | p < 0.001 | 18 (40%) | p = 0.06 |
> 3 (Mild dependency) | 81 (63%) | 54 (52%) | p = 0.14 | 13 (21%) | p = 0.001 | 25 (92%) | 49 (79%) | p = 0.16 | 74 (36%) | p < 0.001 | 56 (67%) | 69 (44%) | p = 0.001 | 23 (43%) | p = 0.01 | 87 (73%) | 50 (39%) | p < 0.001 | 11 (24%) | p < 0.001 |
IC Impairments at baseline (N, %) | ||||||||||||||||||||
Cognitive domain impairment (yes) | 127 (99%) | 70 (68%) | p = 0.006 | 53 (85%) | p = 0.01 | 11 (41%) | 30 (48%) | p = 0.71 | 84 (41%) | p > 0.9 | 39 (46%) | 66 (42%) | p = 0.60 | 20 (38%) | p = 0.41 | 34 (28%) | 62 (48%) | p = 0.002 | 29 (64%) | p < 0.001 |
Psychological domain impairment (yes) | 77 (60%) | 79 (77%) | p = 0.009 | 57 (92%) | p = 0.01 | 5 (19%) | 16 (25%) | p = 0.66 | 60 (29%) | p = 0.33 | 0 (0%) | 38 (24%) | p < 0.001 | 43 (81%) | p < 0.001 | 32 (27%) | 41 (32%) | p = 0.45 | 8 (18%) | p = 0.32 |
Locomotion domain impairment (Yes) | 73 (57%) | 59 (57%) | p > 0.9 | 30 (48%) | p = 0.36 | 8 (30%) | 53 (84%) | p < 0.001 | 101 (50%) | p = 0.08 | 52 (62%) | 84 (53%) | p = 0.26 | 26 (49%) | p = 0.19 | 81 (67%) | 63 (49%) | p = 0.004 | 18 (40%) | p = 0.002 |
Vitality domain impairment | 64 (50%) | 72 (70%) | p = 0.002 | 55 (89%) | p = 0.001 | 11 (41%) | 34 (54%) | p = 0.35 | 146 (72%) | p = 0.002 | 47 (56%) | 108 (69%) | p = 0.06 | 36 (68%) | p = 0.22 | 33 (28%) | 113 (88%) | p < 0.001 | 45 (100%) | p < 0.001 |
Pneumonia (yes) | 28 (22%) | 21 (20%) | p = 0.80 | 6 (10%) | p = 0.04 | 4 (15%) | 54 (86%) | p < 0.001 | 42 (21%) | p = 0.65 | 9 (11%) | 29 (18%) | p = 0.16 | 17 (32%) | p = 0.003 | 18 (15%) | 27 (21%) | p = 0.29 | 10 (22%) | p = 0.38 |
Charlson Comorbidities Index | ||||||||||||||||||||
0 | 41 (32%) | 16 (16%) | p = 0.006 | 6 (10%) | p = 0.002 | 2 (8%) | 17 (27%) | p = 0.07 | 44 (22%) | p = 0.14 | 15 (18%) | 30 (19%) | p = 0.94 | 18 (34%) | p = 0.05 | 26 (21%) | 27 (21%) | p > 0.9 | 10 (22%) | p > 0.9 |
2-Jan | 37 (28%) | 45 (44%) | p = 0.02 | 22 (35%) | p = 0.43 | 15 (56%) | 19 (30%) | p = 0.04 | 70 (34%) | p = 0.05 | 32 (38%) | 55 (35%) | p = 0.74 | 17 (32%) | p = 0.59 | 44 (37%) | 43 (33%) | p = 0.87 | 17 (38%) | p > 0.9 |
4-Mar | 9 (7%) | 2 (2%) | p = 0.13 | 5 (8%) | p > 0.9 | 10 (37%) | 3 (5%) | p < 0.001 | 13 (6%) | p < 0.001 | 4 (5%) | 8 (5%) | p > 0.9 | 4 (8%) | p = 0.76 | 8 (7%) | 4 (3%) | p = 0.30 | 4 (9%) | p = 0.87 |
> 5 | 42 (33%) | 40 (39%) | p = 0.39 | 29 (47%) | p = 0.08 | 0 (0%) | 24 (38%) | p = 0.004 | 77 (38%) | p < 0.001 | 33 (39%) | 64 (41%) | p = 0.93 | 14 (26%) | p = 0.17 | 42 (35%) | 55 (43%) | p = 0.26 | 14 (31%) | p = 0.77 |
Polypharmacy (yes) | 99 (77%) | 72 (70%) | p = 0.30 | 48 (75%) | p > 0.9 | 17 (63%) | 48 (76%) | p = 0.30 | 154 (75%) | p = 0.24 | 67 (80%) | 113 (72%) | p = 0.24 | 39 (74%) | p = 0.52 | 100 (83%) | 91 (71%) | p = 0.02 | 28 (62%) | p = 0.007 |
Comordidity, mean (SD) | 4.93 (2.85) | 4.96 (2.53) | p = 0.84 | 4.82 (2.58) | p = 0.95 | 4.11 (2.43) | 4.39 (1.98) | p = 0.38 | 5.18 (2.86) | p = 0.06 | 4.67 (2.64) | 4.87 (2.78) | p = 0.80 | 5.41 (2.40) | p = 0.04 | 4.78 (2.38) | 5.01 (2.94) | p = 0.82 | 5 (2.68) | p = 0.55 |
GIR (N, %) | ||||||||||||||||||||
2 | 41 (32%) | 38 (37%) | p = 0.49 | 45 (72%) | p < 0.001 | 7 (26%) | 18 (29%) | p > 0.9 | 99 (48%) | p = 0.04 | 26 (31%) | 74 (47%) | p = 0.02 | 24 (45%) | p = 0.12 | 30 (25%) | 66 (51%) | p < 0.001 | 28 (62%) | p < 0.001 |
3 | 26 (20%) | 38 (37%) | p = 0.007 | 10 (16%) | p = 0.63 | 7 (26%) | 10 (16%) | p = 0.41 | 57 (28%) | p > 0.9 | 25 (30%) | 39 (25%) | p = 0.50 | 10 (19%) | p = 0.22 | 33 (28%) | 30 (23%) | p = 0.53 | 11 (24%) | p = 0.84 |
4 | 49 (38%) | 26 (25%) | p = 0.05 | 6 (10%) | p = 0.001 | 8 (30%) | 30 (48%) | p = 0.17 | 43 (21%) | p = 0.44 | 27 (32%) | 37 (24%) | p = 0.19 | 17 (32%) | p > 0.9 | 47 (39%) | 29 (22%) | p = 0.006 | 5 (11%) | p = 0.001 |
5 | 11 (8%) | 1 (1%) | p = 0.02 | 1 (2%) | p = 0.12 | 5 (18%) | 5 (7%) | p = 0.27 | 3 (1%) | p < 0.001 | 5 (6%) | 6 (4%) | p = 0.66 | 2 (4%) | p = 0.86 | 10 (8%) | 3 (2%) | p = 0.06 | 0 (0%) | p = 0.10 |