Table 3 Subgroup ending of clinical outcomes of NOACs versus warfarin in elderly AF patients
NOACs(n = 2656) | warfarin(n = 794) | |||||
|---|---|---|---|---|---|---|
Incident Number (n) | Incident Number (%) | Incident Number (n) | Incidence Rate(%) | Adjusted OR(95% CI) | P-value | |
Thromboembolism | ||||||
AII | 146 | 5.50 | 52 | 6.55 | 0.79(0.57–1.13) | 0.187 |
65 ≤ Age < 74 | 64 | 5.29 | 29 | 5.95 | 0.94(0.59–1.54) | 0.801 |
75 ≤ Age < 84 | 54 | 5.41 | 19 | 7.22 | 0.66(0.38–1.18) | 0.144 |
Age ≥ 85 | 28 | 7.07 | 4 | 9.09 | 0.65(0.22–2.43) | 0.479 |
Male | 73 | 4.71 | 27 | 6.73 | 0.64(0.40–1.04) | 0.065 |
Female | 73 | 6.59 | 25 | 6.36 | 1.01(0.62–1.69) | 0.964 |
BMI < 25 | 106 | 5.75 | 41 | 7.33 | 0.76(0.52–1.14) | 0.171 |
BMI ≥ 25 | 40 | 4.93 | 11 | 4.68 | 1.01(0.50–2.20) | 0.978 |
Hypertension | 105 | 6.15 | 27 | 6.32 | 0.57(0.32–1.03) | 0.057 |
No Hypertension | 41 | 4.32 | 25 | 6.81 | 1.00(0.64–1.60) | 0.996 |
Diabetes | 29 | 4.61 | 7 | 4.43 | 0.81(0.56–1.19) | 0.262 |
No Diabetes | 117 | 5.77 | 45 | 7.08 | 0.84(0.36–2.21) | 0.709 |
Major bleeding | ||||||
AII | 132 | 4.97 | 25 | 3.15 | 1.47(0.93–2.31) | 0.098 |
65 ≤ Age < 74 | 52 | 4.30 | 13 | 2.67 | 1.58(0.85–3.15) | 0.166 |
75 ≤ Age < 84 | 55 | 5.23 | 10 | 3.80 | 1.43(0.73–3.09) | 0.328 |
Age ≥ 85 | 25 | 6.31 | 2 | 4.54 | 1.49(0.38–10.17) | 0.619 |
Male | 78 | 5.04 | 16 | 3.99 | 1.14(0.66–2.09) | 0.655 |
Female | 54 | 4.88 | 9 | 2.29 | 2.28(1.12–5.14) | 0.032 |
BMI < 25 | 84 | 4.55 | 17 | 3.04 | 1.39(0.82–2.50) | 0.243 |
BMI ≥ 25 | 48 | 5.92 | 8 | 3.40 | 1.65(0.79–3.92) | 0.214 |
Hypertension | 87 | 5.09 | 12 | 2.81 | 1.34(0.70–2.73) | 0.394 |
No Hypertension | 45 | 4.75 | 13 | 3.54 | 1.72(0.95–3.39) | 0.090 |
Diabetes | 27 | 4.29 | 2 | 1.27 | 1.39(0.87–2.30) | 0.180 |
No Diabetes | 105 | 5.18 | 23 | 3.62 | 3.45(0.97–22.12) | 0.103 |
Minor bleeding | ||||||
AII | 121 | 4.56 | 52 | 6.55 | 0.69(0.48–0.98) | 0.038 |
65 ≤ Age < 74 | 67 | 5.55 | 37 | 7.59 | 0.73(0.47–1.15) | 0.166 |
75 ≤ Age < 84 | 39 | 3.71 | 14 | 5.32 | 0.58(0.31–1.15) | 0.101 |
Age ≥ 85 | 15 | 3.79 | 1 | 2.27 | 3.77(0.63–74.90) | 0.233 |
Male | 70 | 4.52 | 19 | 4.74 | 0.93(0.55–1.66) | 0.803 |
Female | 51 | 4.61 | 33 | 8.40 | 0.56(0.34–0.91) | 0.018 |
BMI < 25 | 88 | 4.77 | 38 | 6.80 | 0.72(0.47-1.0) | 0.115 |
BMI ≥ 25 | 33 | 4.07 | 14 | 5.96 | 0.64(0.32–1.32) | 0.207 |
Hypertension | 82 | 4.80 | 24 | 5.62 | 0.60(0.35–1.05) | 0.068 |
No Hypertension | 39 | 4.11 | 28 | 7.63 | 0.85(0.531–1.41) | 0.517 |
Diabetes | 24 | 3.82 | 9 | 5.70 | 0.70(0.47–1.04) | 0.071 |
No Diabetes | 97 | 4.79 | 43 | 6.76 | 0.71(0.32–1.69) | 0.408 |