Table 2 Clinical outcomes of NOACs versus warfarin in elderly AF patients
Clinical Outcomes | NOACs(n = 2656) | warfarin(n = 794) | ||||||
|---|---|---|---|---|---|---|---|---|
Incident number(n) | Incidence rate(%/n) | Incident number(n) | Incidence rate(%/n) | OR(95% CI) | P-value | Adjusted OR(95% CI) | Adjusted P-value | |
Thromboembolism | 146 | 5.50 | 52 | 6.55 | 0.83(0.60–1.15) | 0.263 | 0.79(0.57–1.13) | 0.187 |
Total bleeding | 250 | 9.41 | 77 | 9.70 | 1.03(0.78–1.35) | 0.853 | 1.01(0.76–1.35) | 0.947 |
Major bleeding | 132 | 4.97 | 25 | 3.15 | 1.61(1.04–2.47) | 0.031 | 1.51(0.98–2.42) | 0.075 |
Minor bleeding | 121 | 4.56 | 52 | 6.55 | 0.68(0.49–0.95) | 0.024 | 0.70(0.49–1.01) | 0.049 |
Gastrointestinal bleeding | 116 | 4.37 | 20 | 2.52 | 1.77(1.09–2.86) | 0.019 | 1.64(1.02–2.78) | 0.051 |
Intracranial haemorrhage | 18 | 0.68 | 5 | 0.63 | 1.08(0.40–2.91) | 0.884 | 1.06(0.40–3.35) | 0.914 |
All-cause death | 237 | 8.92 | 102 | 12.85 | 0.67(0.52–0.85) | < 0.001 | 0.57(0.44–0.75) | < 0.001 |