Table 1 Baseline characteristics of elderly AF patients with NOACs and warfarin
NOACs (n = 2656) | warfarin (n = 794) | P value | |
|---|---|---|---|
Age | < 0.001 | ||
65–74, n (%) | 1208(45.48) | 487(61.33) | < 0.001 |
75–84, n (%) | 1052(39.61) | 263(33.12) | |
≥ 85, n (%) | 396(14.91) | 44(5.14) | |
Median, Median(25%, 75%) | 75(70–82) | 72(68-77.25) | < 0.001 |
Sex, Femal, n (%) | 1107(41.68) | 393(49.50) | < 0.001 |
BMI, Median(25%, 75%) | 23.31(21.22–25.78) | 23.04(21.20-25.65) | 0.499 |
≥ 25, n (%) | 811(30.53) | 235(29.60) | 0.614 |
<25, n (%) | 1845(69.47) | 559(70.40) | |
Smoking, n (%) | 291(10.96) | 67(8.44) | 0.041 |
Alcohol, n (%) | 332(12.50) | 72(9.07) | 0.008 |
History of bleeding, n (%) | 140(5.27) | 37(4.66) | 0.493 |
Anaemia, n (%) | 733(27.60) | 209(26.32) | 0.479 |
History of ischaemic stroke, n (%) | 657(24.74) | 188(23.68) | 0.543 |
History of TIA, n (%) | 23(0.87) | 11(1.39) | 0.194 |
Hypertension, n(%) | 1708(64.31) | 427(53.78) | < 0.001 |
coronary heart disease, n(%) | 1089(41.00) | 297(37.41) | 0.070 |
Heart failure, n(%) | 1202(45.26) | 432(54.41) | < 0.001 |
Peripheral artery disease, n(%) | 859(32.34) | 224(28.21) | 0.028 |
Active cancer, n(%) | 75(2.82) | 21(2.64) | 0.788 |
COPD, n (%) | 379(14.27) | 105(13.22) | 0.457 |
Diabetes, n(%) | 629(23.68) | 158(19.90) | 0.026 |
Arthrolithiasis, n(%) | 134(5.05) | 30(3.78) | 0.141 |
Hepatic insufficiency, n(%) | 164(6.17) | 34(4.28) | 0.044 |
Renal inadequacy, n(%) | 486(18.30) | 135(17.00) | 0.404 |
Combined medication, n (%) | |||
Antiplatelet drugs, n (%) | 921(34.68) | 324(40.81) | 0.002 |
PPI | 1281(48.23) | 485(61.08) | 0.000 |
Statins | 1757(66.15) | 479(60.33) | 0.003 |
Amiodarone | 297(11.18) | 81(10.20) | 0.438 |
NSAID | 457(17.21) | 149(18.77) | 0.311 |
ACEI | 114(4.29) | 85(10.71) | < 0.001 |
ARB | 899(33.85) | 215(27.08) | < 0.001 |
CCB | 675(25.41) | 186(23.43) | 0.256 |
β-Blockers | 1549(58.32) | 476(59.95) | 0.413 |
Digoxin | 415(15.63) | 262(33.00) | < 0.001 |
score | |||
CHA2DS2-VASc, Median(25%, 75%) | 5(4–6) | 5(3–6) | 0.045 |
CHA2DS2-VASc ≥ 2, n (%) | 2606(98.12) | 786(98.99) | 0.092 |
HAS-BLED, Median(25%, 75%) | 2(1–2) | 1(1–2) | < 0.001 |
HAS-BLED ≥ 3, n (%) | 484(18.22) | 127(15.99) | 0.149 |