Fig. 2

Difference in negative emotion outcomes, pain intensity and frequency between the control group and esketamine group. (A) Comparison of anxiety score between two groups in postoperative day 1 and day 3, *P < 0.05. (B) Comparison of depression score between two groups in postoperative day 1 and day 3, *P < 0.05, **P < 0.01. (C) Comparison of Postoperative 24-hour and 48-hour VAS score between two groups, **P < 0.01, ***P < 0.001. (D) Comparison of postoperative opioid consumption used between two groups, ***P < 0.001. (E) Rescue analgesia rate in two groups, orange area was the number of patients who required postoperative rescue analgesia. (F) Postoperative non-opioid analgesic using rate in two groups, orange area was the number of patients who used non-opioid analgesic