Table 2 Pre-Post MR analysis of medication number, MRCI, DBI

Pharmacological data

Mild dementia

Moderate dementia

Severe dementia

TOTAL

n = 6

n = 35

n = 40

n = 81

Pre-MR

Post-MR

Difference

Pre-MR

Post-MR

Difference

Pre-MR

Post-MR

Difference

Pre-MR

Post-MR

Difference

Number of medication, mean (sd)

6.5 (6.4)

3.5 (3.5)

0.001

8.6 (3.2)

6.3 (2.3)

0.009

7.8 (3.3)

5.4 (2.7)

< 0.001

8.0 (3.5)

5.7 (2.7)

< 0.001

0–4 medications

4 (66.7%)

4 (66.7%)

-

3 (8.6%)

9 (25.7%)

0.023

5 (12.5%)

18 (45%)

< 0.001

12 (14.8%)

31 (38.3%)

< 0.001

5–9 medications

0 (0%)

1 (16.7%)

24 (68.6%)

24 (68.6%)

23 (57.5%)

18 (45%)

47 (58%)

43 (53.1%)

 ≥ 10 medications

2 (33.3%)

1 (16.7%)

8 (22.9%)

2 (5.7%)

12 (30%)

4 (10%)

22 (27.2%)

7 (8.6%)

Mild dementia

Moderate dementia

Severe dementia

TOTAL

n = 6

n = 35

n = 40

n = 81

MRCI, mean (sd)

23 (23.3)

11.5 (11.5)

0.004

31.3 (12.3)

24.4 (11.1)

0.003

28.3 (13.3)

19.3 (10.5)

< 0.001

29.2 (13.8)

20.9 (11.3)

< 0.001

Low complexity (0–19.99)

4 (66.7%)

5 (83.3%)

-

4 (11.4%)

14 (40%)

0.017

11 (27.5%)

24 (60%)

0.002

19 (23.5%)

43 (53.1%)

< 0.001

Moderate complexity (20–39.99)

0 (0%)

1 (16.7%)

24 (68.6%)

19 (54.3%)

24 (60%)

13 (32.5%)

48 (59.3%)

33 (40.7%)

High complexity (≥ 40)

2 (33.3%)

0 (0.0%)

7 (20%)

2 (5.7%)

5 (12.5%)

3 (7.5%)

14 (17.3%)

5 (6.2%)

Mild dementia

Moderate dementia

Severe dementia

TOTAL

n = 6

n = 35

n = 40

n = 81

DBI, mean (sd)

1.38 (1.01)

0.97 (1.02)

0.025

1.37 (0.90)

1.27 (0.97)

< 0.001

1.81 (1.13)

1.36 (0.88)

< 0.001

1.59 (1.04)

1.29 (0.92)

< 0.001

Low DBI (0–0.99)

2 (33.3%)

6 (66.7%)

0.368

13 (37.1%)

14 (40.0%)

0.549

11 (26.8%)

13 (31.7%)

0.050

26 (31.7%)

31 (37.8%)

0.045

Moderate DBI (1–1.99)

2 (33.3%)

1 (16.7%)

14 (40.0%)

15 (42.9%)

17 (41.5%)

20 (48.8%)

33 (40.2%)

36 (43.9%)

High DBI (≥ 2)

2 (33.3%)

1 (16.7%)

8 (22.9%)

6 (17.1%)

13 (31.7%)

8 (19.5%)

23 (28.0%)

15 (18.3%)