Table 2 Most common clinically significant potential drug interactions with risk rating, severity, and clinical implication

ASA-Enalapril

C

Moderate

59

Increased nephrotoxic effect of ACEI

Glibenclamide-Metformin

C

Moderate

41

Increased hypoglycemic effect

Metformin-Enalapril

C

Moderate

40

Risk of hypoglycemia and lactic acidosis

HCT-Enalapril

C

Moderate

19

Increased hypotensive and nephrotoxic effects of ACEI

ASA-insulin

C

Moderate

16

Increased hypoglycemic effect

Diclofenac (topical)-Diclofenac (systemic)

D

Major

2

Increased toxic effects of NSAIDs

Indomethacin-Diclofenac

D

Major

2

Increased toxic effects of NSAIDs