Serum ALT activity and its isoenzymes as potential biomarkers for diagnosis of Sarcopenia in older adults: a retrospective, cross-sectional study

Table 3 Odds ratio of low HGS, low physical performance, low ASMI and Sarcopenia by trisection of ALT activity and ALT1/ALT2

		Low HGS		Low Physical Performance		Low ASMI		Sarcopenia
		OR (95%CI)	p	OR (95%CI)	p	OR (95%CI)	p	OR (95%CI)	p
ALT tertiles	Model 1	0.679 (0.535, 0.861)	0.001	0.654 (0.538, 0.794)	< 0.001	0.584 (0.447, 0.763)	< 0.001	0.591 (0.486, 0.720)	< 0.001
	Model 2	0.711 (0.556, 0.909)	0.007	0.654 (0.533, 0.803)	< 0.001	0.574 (0.417, 0.792)	0.001	0.625 (0.509, 0.767)	< 0.001
	Model 3	0.713 (0.558, 0.912)	0.007	0.653 (0.532, 0.802)	< 0.001	0.559 (0.403, 0.774)	< 0.001	0.624 (0.508, 0.767)	< 0.001
ALT1/ALT2 tertiles	Model 1	1.341 (0.785, 2.292)	0.283	2.305 (1.388, 3.826)	0.001	1.266 (0.643, 2.492)	0.495	2.138 (1.301, 3.514)	0.003
	Model 2	1.474 (0.794, 2.738)	0.219	3.135 (1.701, 5.776)	< 0.001	0.969 (0.405, 2.319)	0.943	2.373 (1.323, 4.258)	0.004
	Model 3	1.611 (0.838, 3.097)	0.153	3.417 (1.814, 6.436)	< 0.001	0.973 (0.394, 2.406)	0.973	2.554 (1.399, 4.663)	0.002

Model 1: crude. Model 2: adjusted for age, sex, and BMI. Model 3: adjusted for Model 2 + diabetes, osteoporosis. ALT tertiles: ALT activity tertiles (Tertile 1 ≤ 13.80 U/L, Tertile 2 13.81–19.80 U/L, Tertile 3 ≥ 19.81 U/L); ALT1/ALT2: ALT1/ALT2 ratio tertiles (Tertile 1 ≤ 0.99, Tertile 2 1.00-1.22, Tertile 3 ≥ 1.23). Abbreviations: OR, odds ratio; 95% CI, 95% confidential interval; ALT, alanine aminotransferase; HGS, hand grip strength; ASMI, appendicular skeletal muscle mass index; BMI, body mass index

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