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Table 4 Clinical phenotypes of older patients with psychotropic prescriptions admitted for hip fracture (comparisons carried out with Chi-squared test for categorical variables, or with ANOVA or Kruskal-Wallis test for continuous variables, as appropriate)

From: Deprescribing psychoactive drugs in older orthogeriatric patients: findings from the GIOG2.0 Italian survey

 

Polypharmacy

Dementia

Fit

Very severe

 

Cluster N

1

2

3

4

p

N

155

149

176

121

 

Age (years), mean(SD)

83.2 (6.6)

86.7 (6.4)

82.1 (7.5)

85.2 (6.2)

0.859

Sex (Female), n (%)

120 (77%)

125 (84%)

147 (84%)

98 (81%)

0.427

Dementia, n(%)

21 (14%)

129 (87%)

22 (12%)

108 (89%)

< 0.001

ADL, median(IQR)

5 (4–6)

2 (1–3)

6 (5–6)

1 (1–2)

< 0.001

Delirium in 72h after surgery, n(%)

22 (14%)

114 (77%)

21 (12%)

98 (81%)

< 0.001

Polypharmacy >5 at admission, n(%)

155 (100%)

0 (0%)

0 (0%)

121 (100%)

< 0.001

Hospitalization length, median (IQR)

11 (8–14)

9 (7–12)

9 (7–12)

10 (7–14)

< 0.001

MNA, n(%)

    

< 0.001

 Well-nourished

58 (40%)

14 (10%)

72 (43%)

15 (13%)

 At risk

73 (50%)

96 (70%)

80 (48%)

76 (68%)

 Malnourished

15 (10%)

28 (20%)

16 (10%)

21 (19%)

CCI, median(IQR)

5 (4–7)

6 (5–7)

4 (4–6)

6 (5–8)

< 0.001

Diabetes Mellitus, n(%)

42 (27%)

31 (21%)

17 (10%)

32 (27%)

< 0.001

CKD (Moderate-severe), n(%)

20 (13%)

19 (13%)

9 (5%)

26 (22%)

< 0.001

CHF, n(%)

20 (13%)

16 (11%)

14 (8%)

19 (16%)

0.2

Myocardial Infarction, n(%)

29 (19%)

22 (15%)

7 (4%)

30 (25%)

< 0.001

COPD, n(%)

18 (12%)

11 (7%)

13 (7%)

10 (8%)

0.472

Peripheral vascular disease, n(%)

29 (19%)

22 (15%)

21 (12%)

15 (12%)

0.274

ADL disabilitya, n(%)

47 (30%)

138 (93%)

24 (14%)

112 (93%)

< 0.001

Setting at discharge, n(%)

    

0.125

 Home

56 (43%)

43 (38%)

46 (30%)

36 (43%)

 Rehabilitation

75 (57%)

70 (62%)

105 (70%)

48 (57%)

N Drugs at admission, median(IQR)

8 (7–9)

4 (2–5)

3 (2–4)

7 (6–9)

< 0.001

  1. Abbreviations: MNA mini nutritional assessment, CCI Charlson comorbidity index
  2. adefined as the pre-existing loss of at least 2 activities of daily living