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Table 3 Associated factors of deprescribing

From: Deprescribing psychoactive drugs in older orthogeriatric patients: findings from the GIOG2.0 Italian survey

Reduction in psychoactive drugs at discharge

  
 

OR

aOR

N

177

 

Age (years), mean(SD) 

1 (0.98–1.02), 0.821

 

Sex (Female), n (%) 

1.54 (1.04–2.36), 0.038

1.55 (0.96–2.59), 0.081

MNA, n(%) 

 At risk

1.22 (0.84–1.81), 0.306

 

 Malnourished

1.66 (0.97–2.79), 0.057

0.9 (0.51–1.54), 0.681

ADL, median(IQR) 

0.84 (0.78–0.91), 0

0.87 (0.78–0.97), 0.014

CCI, median(IQR) 

1.15 (1.07–1.24), 0

0.99 (0.87–1.13), 0.906

Diabetes Mellitus, n(%)

1.12 (0.76–1.6), 0.563

 

CKD (Moderate-severe), n(%)

1.17 (0.73–1.81), 0.485

 

CHF, n(%) 

1.53 (0.96–2.33), 0.06

0.91 (0.5–1.63), 0.733

Myocardial Infarction, n(%)

0.85 (0.54–1.29), 0.459

 

COPD, n(%)

0.91 (0.49–1.56), 0.751

 

Peripheral vascular disease, n(%)

1.64 (1.09–2.42), 0.015

1.47 (0.83–2.55), 0.16

Dementia, n(%) 

1.72 (1.24–2.38), 0.001

1.18 (0.72–1.93), 0.499

Setting at discharge, n(%)

 Rehabilitation

0.93 (0.63–1.38), 0.696

 

Delirium in 72h after surgery, n(%)

2.14 (1.56–2.93), 0

1.71 (1.09–2.66), 0.017

N Drugs at admission, median(IQR)

1.15 (1.09–1.21), 0

1.15 (1.03–1.29), 0

Polypharmacy >5 at admission, n(%)

2.32 (1.69–3.2), 0

 

Enrolling centersa

 01

ref

ref

 02

1.67 (0.95–2.87), 0.069

2.65 (1.19–5.74), 0.013

 04

1.45 (0.9–2.33), 0.123

1.12 (0.62–1.97), 0.716

 06

0.99 (0.42–2.1), 0.984

0.94 (0.38–2.07), 0.881

 08

0.7 (0.44–1.12), 0.133

0.6 (0.34–1.04), 0.052

 10

0.2 (0.06–0.51), 0.003

0.15 (0.04–0.41), 0.001

 13

0.69 (0.2–1.78), 0.487

1.18 (0.33–3.34), 0.767

  1. Abbreviations: MNA mini nutritional assessment, CCI Charlson comorbidity index
  2. aCenters recruiting at least 50 patients