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Table 3 Parameters identified as significantly different in univariate analysis among TSH categories

From: Evaluation of the effects of thyroid functions on frailty in geriatric patients using the Edmonton, SOF and FRAIL Scales

 

Category 1 (n=48) (TSH<0.5)

Category 2 (n=102) (TSH: 0.5-3)

Category 3 (n=33) (TSH: 3-6)

Category 4 (n=16) (TSH: 6-10)

Category 5 (n=21) (TSH>10)

P value

SOF frailty scale, n (%)

      

Robust

9 (18.8)

50 (49.0)

14 (42.4)

0 (0)

0 (0)

<0.001

 Prefrail

8 (16.7)

23 (22.5)

9 (27.3)

2 (12.5)

7 (33.3)

 Frail

31 (64.6)

29 (28.4)

10 (30.3)

14 (87.5)

14 (66.7)

Edmonton frailty scale, n (%)

      

 Robust

19 (39.6)

62 (60.8)

19 (57.6)

4 (25.0)

1 (4.8)

<0.001

 Prefrail

9 (18.8)

16 (15.7)

6 (18.2)

7 (43.8)

10 (47.6)

 Mild frail

16 (33.3)

15 (14.7)

4 (12.1)

2 (12.5)

6 (28.6)

 Moderate frail

3 (6.3)

6 (5.9)

2 (6.1)

2 (12.5)

4 (19.0)

 Severe frail

1 (2.1)

3 (2.9)

2 (6.1)

1 (6.3)

0 (0)

FRAIL frailty scale, n (%)

     

<0.001

 Robust

9 (18.8)

42 (41.2)

12 (36.4)

0 (0)

0 (0)

 Prefrail

14 (29.2)

39 (38.2)

9 (27.3)

9 (56.3)

6 (28.6)

 Frail

25 (52.1)

21 (20.6)

12 (36.4)

7 (43.8)

15 (71.4)

Hypothyroidism, n (%)

9 (18.8)

9 (8.8)

10 (30.3)

9 (56.3)

17 (81.0)

<0.001

bfT4, ng/dL

1.47

1.19

1.19

0.99

1.11

<0.001

bfT3, pg/mL

2.96

2.67

2.81

2.27

2.15

0.002

bfT3/fT4 ratio

1.97

2.20

2.42

2.40

2.48

0.009

Anti-TPO positivity, n (%)

18 (37.5)

16 (15.7)

8 (24.2)

7 (43.8)

14 (66.7)

<0.001

bMedian years of thyroid medication use

0

0

0

5.5

4

<0.001

aPeripheral vascular disease, n (%)

0 (0)

10 (9.8)

2 (6.1)

0 (0)

0 (0)

0.004

aGraves’ Disease, n (%)

14 (29.2)

2 (2.0)

0 (0)

1 (6.3)

0 (0)

<0.001

aHistory of thyroid surgery, n (%)

7 (14.6)

3 (2.9)

3 (9.1)

7 (43.8)

5 (23.8)

<0.001

aHistory of radioactive iodine treatment, n (%)

5 (10.4)

1 (1.0)

1 (3.0)

2 (12.5)

2 (9.5)

0.004

  1. Anti-TPO Thyroid peroxidase antibody, FRAIL Fatigue-resistance-ambulation-illness-loss of weight, fT3 Free triiodothyronine, fT4 Free thyroxine, SOF Study of osteoporotic fractures, TSH Thyroid-stimulating hormone 
  2. aFisher's exact test was used to evaluate these parameters. The chi-square test was used for other categorical comparisons. P values are from the respective tests
  3. bFor the intergroup comparisons of these parameters, the Jonckheere-Terpstra test was applied. The percentages presented in the table are pertinent to the groups in each column
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