Table 2 Bivariate analysis by categorical age (60–70, 71–80 and > 80 years)
60-70 years (n=618) (39.5%) | 71-80 years (n=557) (35.6%) | >80 years (n=388) (24.8%) | p value | |
|---|---|---|---|---|
Patients | Patients | Patients | ||
Demographic | ||||
Sex n (%) | Female | Female | Female | 0.041+ |
211(34.1%) | 183(32.8%) | 157(40.4%) | ||
Male | Male | Male | ||
407(65.8%) | 374(67.1%) | 231(59.5%) | ||
Age (years) median [IQR] | 65[62-68] | 75[73-78] | 85[82-88] | < 0.001* |
Body mass index median [IQR] | 26.7[24.2-29.7] | 26.5[24.0-29.3] | 25.2[23.1-28.0] | < 0.001* |
Comorbidities | ||||
Hypertension n (%) | 159(25.7%) | 184(33.0%) | 131(33.7%) | 0.005+ |
Congestive heart Failure n (%) | 27(4.3%) | 29(5.2%) | 30(7.7%) | 0.069+ |
Chronic pulmonary disease n (%) | 24(3.8%) | 52(9.3%) | 48(12.3%) | <0.001+ |
Diabetes n (%) | 129(20.8%) | 98(17.5%) | 51(13.1%) | 0.007+ |
Charlson Index median [IQR] | 2[2-3] | 3[3-4] | 4[4-5] | <0.001* |
Laboratory values median (IQR) | ||||
White blood count (cells x 106/L) | 9070[6855-12095] | 8475[6228-11842] | 8260[6070-11650] | 0.005* |
Neutrophil-lymphocyte ratio | 9.05[5.75-13.82] | 8.57[4.82-14.65] | 8.86[4.87-16.09] | 0.42* |
Hematocrit (%) | 44.1[40.2-47.6] | 44.1[39.8-47.6] | 41[36.9-45.7] | <0.001* |
Hemoglobin (g/dl) | 14.8[13.5-16] | 14.7[13.4-15.9] | 13.6[12.3-15.2] | <0.001* |
LDH (U/L) | 452.5[352.2-568] | 421[333-530] | 381[299-497] | <0.001* |
D dimer (ng/ml) | 1085[677-2024] | 1204[758-2052] | 1545 [899-2889] | <0.001* |
Procalcitonin (ng/ml) | 0.42[0.17-1.2] | 0.43[0.17-1.5] | 0.39[0.11-1.37] | 0.65* |
Ferritin (ng/ml) | 1436[863.5-2409] | 978.5[604.1-1782.2] | 962.9[545.7-1977] | 0.003* |
Oxygenation index median [IQR] | ||||
P/F ratio at admission | 170.0[110.5-222.6] | 168[108.9-232.2] | 171.5[102.6-228.2] | 0.7* |
P/F ratio at the diagnosis of ARDS | 168.7[110.2-218.1] | 165.4[108.5-227.6] | 165.3[99.9- 221.7] | 0.47* |
Lowest P/F ratio | 70.1[53.4-118.4.] | 72.0[54.4-121.5] | 81.6[60.6-143.7] | 0.00015* |
C-ARDS | ||||
Mild n (%) | 207(33.4%) | 206(36.9%) | 137(35.3%) | 0.07+ |
Moderate n (%) | 290(46.9%) | 242(43.4%) | 153(39.4%) | 0.07+ |
Severe n (%) | 121(19.5%) | 109(19.5%) | 98(25.2%) | 0.07+ |
Oxygen support strategy | ||||
Mechanical ventilation n (%) | 358(57.9%) | 293(52.6%) | 76(19.5%) | < 0.01+ |
Tracheostomy n (%) | 35(9.7%) | 27(9.2%) | 4(5.2%) | < 0.01+ |
Treatment | ||||
Any steroid n (%) | 491(79%) | 441(79%) | 316(81%) | 0.659+ |
Respiratory mechanics Day 0 median [IQR] | ||||
Tidal volume (mL) | 410[370-450] | 400[370-450] | 400[360-422.5] | 0.060* |
Tidal volume adjusted by ideal weight (mL/kg) | 7[6.5-7.5] | 7[6.5-7.5] | 7.1[6.6-8.1] | 0.116* |
Respiratory rate | 18[16-18] | 18[16-19] | 16[16-18] | 0.008* |
Plateau pressure (cmH2O) | 24[22-26] | 23[21-25] | 22[20-24] | 0.040* |
Peak pressure (cmH2O) | 28[25-32] | 28[25-32] | 27[23.5-30] | 0.350* |
PEEP (cmH2O) | 12[10-12] | 12[10-12] | 10[10-12] | 0.016* |
Driving pressure (cmH2O) | 12[10-14] | 12[10-14] | 11[9.2-13] | 0.257* |
Mechanic power | 15.4[12.7-19.1] | 15.9[13-18.6] | 14.6[12.2-16.8] | 0.168* |
Prone (hours/day) | 0[0-6] | 0[0-1] | 0[0-3] | 0.296* |
Outcomes | ||||
Mortality | 271(43.8%) | 288(51.7%) | 252(64.9%) | < 0.01+ |
Duration of mechanical ventilation (days) median [IQR] | 10[6-15] | 9[4-14] | 7[3-12] | <0.001* |