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Table 1 Effect of 8-week intervention with PR-diet and C-diet on biomarkers under study

From: A (poly)phenol-rich diet reduces serum and faecal calprotectin in older adults with increased intestinal permeability: the MaPLE randomised controlled trial

Variables (n = 51)

Before PR-diet median (IQR)

After PR-diet median (IQR)

Median change

PR group

(95% CI)

Before C-diet median (IQR)

After

C-diet median (IQR)

Median change

C group (95% CI)

Median difference between groups

p-value within PR group

p-value within

C

group

p-value between groups

Calprotectin (ng/mL)

782.20 (595.05)

684.80 (619.80)

-101.6

“-155.2 to -57.10”

735.00 (572.95)

751.90 (566.20)

-17.90

“-100.4 to 41.80”

-104.1

“-227.6 to 2.400”

0.0072

> 0.9999

0.0186#

Faecal Calprotectin (µg/g)

58.48 (115.45)

35.94 (65.74)

-12.48

“-30.79 to -3.708”

46.58 (119.01)

40.78 (114.41)

-3.004

“-10.70 to 6.620”

-9.240

“-22.58 to -0.7620”

0.0007

0.5929

0.0378#

sCD14

(µg/mL)

2.41 (0.77)

2.38 (0.75)

-0.02000

“-0.1000 to 0.07000”

2.36 (0.74)

2.42 (0.72)

0.000

(-0.7000 to 1.200)

0.02000

“-0.2300 to 0.09000”

0.2504

0.9453

0.2097

VE-cadherin* (ng/mL)

224.50 (123.45)

200.55 (116.90)

-11.98

“-25.25 to 1.296”

205.30 (121.42)

206.80 (112.30)

-5.425

“-21.24 to 10.39”

-6.684

“-30.01 to 16.64”

0.0380

0.4941

0.2837

ZO-1

(ng/mL)

1.36 (1.67)

1.68 (1.06)

0.5050

“0.2400 to 0.7600”

1.21 (1.24)

1.75 (1.33)

0.2700

“0.1200 to 0.7500”

0.1420

“-0.3590 to 0.3799”

0.0052

0.0084

0.4529

Occludin (ng/mL)

4.48 (2.27)

4.32 (2.55)

0.01000

“-0.06000 to 0.1500”

4.36 (2.70)

4.46 (2.96)

0.06000

“-0.05000 to 0.2500”

-0.01900

“-0.3000 to 0.1160”

0.3679

0.1333

0.1018

Adiponectin (µg/mL)

5.93 (3.69)

5.33 (4.25)

-0.07000

“-0.2800 to 0.1600”

5.49 (4.13)

5.19 (4.46)

0.05000

“-0.2100 to 0.2300”

0.000

“-0.6700 to 0.2400”

0.1364

0.8314

0.1353

IL-6R

(ng/mL)

23.89 (13.68)

23.34 (14.85)

0.7400

“-0.9400 to 2.040”

23.04 (15.99)

22.63 (13.02)

1.110

“-0.4200 to 2.260”

-0.5900

“-2.710 to 1.100”

0.5816

0.4357

0.3119

LBP

(ng/mL)

9.96 (5.75)

9.61 (4.18)

0.3450

“-0.2800 to 1.140”

10.34 (6.04)

10.21 (5.47)

0.205

“-0.8300 to 1.050”

-0.4500

“-1.270 to 0.310”

0.1427

0.9828

0.1400

  1. All data are expressed as median and interquartile range (IQR). Differences within groups were assessed using the Wilcoxon matched-pairs signed rank test. Data with asterisk are significantly different (p < 0.05). Values in 95% CI of the difference represent differences of the medians (Hodges-Lehmann estimate) for continuous variables
  2. PR, (poly)phenol-rich diet; C, control diet; soluble cluster of differentiation 14 (sCD14); vascular endothelial-cadherin (VE-cadherin); zonula occludens-1 (ZO-1); interleukin-6 receptor (IL-6R); lipopolysaccharide-binding protein (LBP)
  3. *Variable is normally distributed. Paired t-test has been used instead of the Wilcoxon matched-pairs signed rank test. Mean of differences has been reported instead of the median of differences
  4. #Friedman test has been used to corroborate the Wilcoxon matched-pairs signed rank test and both tests are statistically significant (p < 0.05)
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BMC Geriatrics

ISSN: 1471-2318

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